This kind of exchange will make up the bulk of your social media. Users will comment in very specific ways, relevant to their self-interests. The likely path is always some positive and some negative; you'll need to be prepared with a response for both. When posting new or easily misunderstood information, there will likely be questions. Be prepared for those, too.
When a question comes up, respond with truthful answers. Let the audience know you're looking into the question. This may require some research but be timely in your response to ensure no one can answer with false information or troll the post before you respond.